tcsA — Verticillium dahliae

Summary

VDAG_01858 (tcsA) in Verticillium dahliae encodes a virulence sensor protein bvgS with histidine kinase activity, osmosensor activity, peroxide sensor activity, and phosphorelay sensor kinase activity. It contains PAS-like and histidine kinase domains. The gene is associated with the cellular HOG response, osmolarity sensing via a two-component system, activation of the p38 cascade, histidyl-aspartyl phosphorelay, regulation of conidium formation, ascospore formation, filamentous growth in response to starvation and biotic stimulus, cell wall organization, and morphogenesis. The encoded protein localizes to the plasma membrane, cytoplasm, cytosol, cell tip, and cell division site. Studies of related genes in other species link the family to two-component system signaling and histidine kinase activity (EC 2.7.13.3).