PPOA — Verticillium dahliae

Summary

VDAG_02241, designated VdPPOA (also known as PPOC, VdPPOC, VdPPOB, PPOB, PPOA) in Verticillium dahliae, encodes a linoleate diol synthase. The enzyme possesses linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, fatty acid peroxidase, peroxidase, dioxygenase, isomerase, oxidoreductase, monooxygenase, and heme-binding activities. VdPPOA is associated with oxylipin and prostaglandin biosynthesis, secondary metabolism, and the regulation of both asexual and sexual sporulation, including positive regulation of conidia formation and negative regulation of sexual spore formation. It is also linked to fatty acid and long-chain fatty acid metabolism, hydrogen peroxide catabolism, and the oxidative stress response. Studies of related genes in other species connect the family to virulence modulation, including hypervirulence and reduced virulence, and to plant and animal pathogenesis.