SOD1 — Verticillium dahliae

Summary

VDAG_02630, designated VdSOD1 (also known as SOD-1 or VdSOD-1) in Verticillium dahliae, encodes a copper/zinc superoxide dismutase, an enzyme with superoxide dismutase activity and oxidoreductase activity acting on sulphur-group donors with oxygen as acceptor, and binds copper. The gene is associated with cellular response to oxidative stress, detoxification, cell redox homeostasis, removal of superoxide radicals, and copper ion transport and homeostasis. It is linked to fungal-type cell wall organization, secretion, cell death, Golgi reassembly, protein stabilization, and positive regulation of transcription by RNA polymerase II. The product localizes to the cytoplasm, cytosol, nucleus, extracellular region, and mitochondrial envelope lumen. VdSOD1 is associated with vascular wilt disease in cotton (Gossypium hirsutum) and Nicotiana benthamiana, and has been associated with decreased spore germination, increased necrotic cell death, and altered cell cycle progression.