SHO1 — Verticillium dahliae

Summary

VDAG_02794, designated VdSHO1, encodes a protein containing an SH3 domain characteristic of the Sho1 family. In Verticillium dahliae, this gene is associated with the regulation of actin polymerization and melanin anabolism, and its product localizes to the plasma membrane. VdSHO1 is associated with the osmosensory signaling pathway via the Sho1 osmosensor. Phenotypic associations link the gene to defects in osmotic and oxidative stress resistance, alkaline pH resistance, toxin resistance, biofilm formation, anaerobic growth, and flocculation, as well as abnormal filamentous growth, budding, cytokinesis, cell cycle progression, endocytosis, mating efficiency, and septum formation. Studies of related genes in other species have linked the family to reduced virulence and oxidative stress response.