CDC5 — Verticillium dahliae

Summary

VDAG_03138 (VdCDC5, also known as VdPLKA) on chromosome DS572699 of Verticillium dahliae encodes a serine/threonine-protein kinase plo1, with protein kinase activity, histone H3S10 kinase activity, and phospholipid binding. The gene is associated with multiple cell cycle processes including regulation of mitotic actomyosin contractile ring assembly, upregulation of mitotic cytokinesis, spindle assembly checkpoint, sister chromatid segregation, and meiotic spindle pole body organization. It is linked to the sphingolipid-mediated signaling pathway and virus-induced post-transcriptional gene silencing. The encoded protein localizes to the spindle midzone, inner kinetochore, septin ring, and CPC complex. Related genes in other species link the family to cell cycle regulation and cytokinesis.