PRNC — Verticillium dahliae

Summary

VDAG_03218, designated PRNC (VdPRNC), encodes a member of the P5CDH/ALDH4A1 family of aldehyde dehydrogenases, specifically an L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) with betaine-aldehyde and NAD(P)+-dependent aldehyde dehydrogenase activities. In Verticillium dahliae, this gene is associated with phenylpropanoid metabolism, cellular responses to amino acid starvation, carbon catabolite activation of transcription, ethanol and acetaldehyde breakdown, threonine breakdown, osmotic response, antibiotic anabolism, and meiotic cell cycle. The product localizes to mitochondria, cytosol, nucleus, and extracellular space. VdPRNC is linked to vascular wilt in Gossypium hirsutum. Associations from unrecorded sources connect this gene to altered stress resistance (freeze-thaw, desiccation, oxidative, osmotic, UV, heat), nitrogen utilization, mitochondrial genome maintenance, replicative and chronological lifespan, competitive fitness, and chemical resistance.