HH1 — Verticillium dahliae

Summary

VDAG_03445, designated VdHH1, encodes a serine/threonine-protein kinase with dual-specificity kinase activity, annotated as an RNA polymerase II C-terminal domain S2 kinase and a cyclin-dependent kinase. In Verticillium dahliae, VdHH1 is associated with ethylene anabolism, positive regulation of mRNA splicing via the spliceosome, downregulation of protein localisation to the plasma membrane and cell tip, peptidyl-serine phosphorylation, regulation of mitochondrion organisation, G2 cell size control, meiotic cell cycle modulation, negative regulation of the G1/S transition and the cell integrity MAPK cascade, and positive regulation of mitotic cytokinesis site selection. The protein localises to the nuclear cyclin-dependent protein kinase holoenzyme complex, Ctk complex, spliceosome, cytoskeleton, actomyosin contractile ring, and sites of polarised growth. Related genes in other species are linked to increased virulence.