YHM2 — Verticillium dahliae

Summary

VDAG_03947 (VdYHM2) on chromosome DS572700 of Verticillium dahliae encodes a mitochondrial DNA replication protein YHM2 with citrate:2-oxoglutarate antiporter activity, succinate:fumarate antiporter activity, 2-oxoglutarate transporter activity, and DNA binding. The protein localises to the mitochondrial inner membrane and nucleoid, and is associated with mitochondrial citrate transmembrane transport, 2-oxoglutarate transport, and virus-induced post-transcriptional gene silencing. VdYHM2 is linked to numerous phenotypes including decreased colony size, abnormal colony shape, increased polyploidy, abnormal chromosome segregation, increased mutation frequency, increased autophagy, decreased pseudohyphal growth, altered carbon and nitrogen source utilisation, decreased respiratory metabolism, delayed cell cycle progression, and decreased acquired thermotolerance. Related genes in other species connect it to mitochondrial genome maintenance, mitotic recombination, and peroxisomal morphology.