RAV1 — Verticillium dahliae

Summary

VDAG_04073 (VdRAV1) on Verticillium dahliae chromosome DS572700 encodes a regulator of V-ATPase in vacuolar membrane protein, a component of the RAVE complex containing WD40 repeat domains. The gene is associated with vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly, phenylpropanoid anabolism, and lignin anabolism. It localises to the RAVE complex, endosome membrane, endomembrane system, cytoplasm, cytosol, and nucleus. Phenotypic associations include absent vacuolar transport and protein secretion, increased acid pH resistance and biofilm formation, decreased cell cycle progression in G2 phase, increased starvation resistance, and abnormal Golgi and endomembrane morphology. Studies of related genes in other species link the family to vacuolar transport, endocytosis, vegetative growth, calcium sensitivity, phosphate content, and oxidative stress response.