HSC82 — Verticillium dahliae

Summary

VDAG_04645 (HSC82, VdHSC82) encodes an ATP-dependent protein folding chaperone of the Hsp90 family. In Verticillium dahliae, this gene is associated with protein folding, stabilization, and assembly of multidomain proteins, proteasomes, and Box C/D snoRNPs. It is linked to cellular responses to heat and xenobiotic stimuli, filamentous growth, ergosterol biosynthesis, homologous recombination, and regulation of apoptosis. The protein localizes to the hyphal cell wall, cross walls, extracellular vesicles, mitochondria, and the perinuclear cytoplasm. Associations with traits include amino acid content, and phenotypes such as altered cell cycle progression, premature apoptosis, abnormal flocculation, decreased hypoosmotic stress resistance, increased thermotolerance, and abnormal spore germination. Studies of related genes in other species link the Hsp90 family to reduced virulence and oxidative stress responses.