FREB — Verticillium dahliae

Summary

VDAG_04862 (FREB) in Verticillium dahliae encodes a ferric-chelate reductase (NADPH) (EC 1.16.1.9), a member of the ferric/cupric reductase family with FAD- and NAD-binding domains. The enzyme is annotated with ferric-chelate reductase (NADPH) activity and metal binding, and is localized to the plasmalemma. FREB is associated with copper ion import, cellular iron ion homeostasis, and iron transport. The gene is linked to the related gene CFL1 and to frp2. Studies of related genes in other species, including those from Fusarium species, connect the family to reduced virulence and vascular wilt in Nicotiana benthamiana.