SIB2 — Verticillium dahliae

Summary

VDAG_05313 (VdSIB2, also known as VdSIDA or VdSID1) in Verticillium dahliae encodes an L-ornithine N(5)-monooxygenase [NAD(P)H], a member of the Lys/Orn_oxygenase family with FAD/NAD-binding domains. The enzyme exhibits ornithine N5-monooxygenase activity (EC 1.14.13.196), N,N-dimethylaniline monooxygenase activity, NADP+ binding, iron binding, and redox activity. This gene is associated with ferrichrome and siderophore biosynthesis, siderophore-iron import into cells, cellular response to iron ion starvation, iron homeostasis, induced systemic resistance, oxidative stress response, ergosterol biosynthesis, and secondary metabolite production. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, though this is not established for VdSIB2 itself.