MMS2 — Verticillium dahliae

Summary

VDAG_05365 (VdMMS2) on chromosome DS572704 of Verticillium dahliae encodes a ubiquitin-conjugating enzyme (EC 2.3.2.23) with a UBC domain and a UBQ-conjugating_enzyme/RWD domain. The gene is annotated to protein K63-linked ubiquitination, DNA damage tolerance, and localises to the ubiquitin-conjugating enzyme complex, cytosol and nucleus. VdMMS2 is associated with numerous phenotypes including absent X-ray and UV resistance, delayed sporulation, abnormal cell cycle progression, decreased meiotic recombination, absent mating-type switching, arrested meiosis, abnormal chronological lifespan, and decreased ribophagy. It is also linked to altered mitochondrial transport, telomere length, and chromosome segregation. Studies of related genes in other species connect the MMS2 family to DNA repair pathways involving REV1, REV7, POL31, and components of the SMC5-SMC6 complex.