GLO1 — Verticillium dahliae

Summary

VDAG_05581 (GLO1, VdGLO1) on Verticillium dahliae chromosome DS572704 encodes a glyoxalase I enzyme with lactoylglutathione lyase activity (EC 4.4.1.5) and metal binding capability, belonging to the VOC glyoxalase family. The gene is associated with cellular detoxification, the cellular osmotic response, and localises to both the cytosol and nucleus. Associations with numerous phenotypes include decreased filamentous and invasive growth, altered carbon and nitrogen source utilisation, increased cold sensitivity, decreased oxidative stress resistance, decreased toxin and metal resistance, altered chronological lifespan, and increased competitive fitness. The gene is also linked to decreased fermentative and respiratory growth, increased chemical compound excretion, and decreased vegetative growth rate. Studies of related genes in other species connect the family to heat sensitivity and oxidative stress response.