CAT1 — Verticillium dahliae

Summary

VDAG_05792 (VdCAT1, also known as CTT1, CTA1) encodes a peroxisomal catalase, a heme-binding enzyme with catalase activity that detoxifies hydrogen peroxide. In Verticillium dahliae, VdCAT1 is associated with hydrogen peroxide metabolic and catabolic processes, the metabolic burst, cellular detoxification of hydrogen peroxide, and responses to hydrogen peroxide. It is linked to fumigaclavine C and indole alkaloid biosynthesis, alkaloid metabolism, filamentous growth in response to chemical stimuli and starvation, cellular response to starvation, and interaction with the host. The gene product localizes to the peroxisomal lumen, peroxisome, mitochondria, mitochondrial lumen, fungal-type cell wall, and cytoplasm. Phenotypic associations include increased pexophagy, increased entry into G0 phase, increased cell cycle progression in G1, increased survival in stationary phase, increased ionic stress resistance, increased starvation resistance, decreased utilization of sulfur sources, decreased fermentative metabolism, decreased mitochondrial transport, decreased protein transport, decreased pheromone-induced cell cycle arrest, absent oxidative stress resistance, absent silencing, and sterility.