FRDA — Verticillium dahliae

Summary

VdFRDA (VDAG_06038) on chromosome DS572707 of Verticillium dahliae encodes an osmotic growth protein with fumarate reductase (NADH) activity and FMN binding, belonging to the FAD-oxidoreductase_2 and succinate dehydrogenase/fumarate reductase catalytic domain families. The gene is associated with fumarate metabolism and localised to mitochondria, cytoplasm, cytosol and nucleus. It is associated with numerous phenotypes including increased hyperosmotic stress resistance, increased acid pH resistance, increased viability and lifespan, decreased necrotic cell death, decreased apoptosis, increased mitophagy, abnormal colony colour, decreased fermentative and respiratory metabolism, abnormal mitochondrial genome maintenance, and increased mitotic recombination. Studies of related genes in other species link the family to turgor pressure, germination rate and oxidative stress response.