TIPA — Verticillium dahliae

Summary

VDAG_06490, designated VdTIPA, encodes a Type 2A phosphatase activator TIP41 protein belonging to the TIP41-like family and possesses protein phosphatase activator activity. In Verticillium dahliae, this gene is associated with TOR signaling and downregulation of TORC1 signaling, and its product localizes to both the cytosol and nucleus. The gene is associated with abnormal cell cycle progression, altered endocytosis, decreased spore germination, increased osmotic stress resistance, and increased lifespan. Additional associations include abnormal colony shape, decreased protein secretion, altered RNA modification, and reduced resistance to UV and ionizing radiation. Related genes in other species are linked to vegetative growth arrest, increased filamentous growth, and decreased thermotolerance.