FREB — Verticillium dahliae

Summary

VDAG_06616 (FREB) on chromosome DS572708 of Verticillium dahliae encodes a ferric/cupric reductase family protein with NADH:Fe³⁺ oxidoreductase and iron chelate reductase activities, and binds FAD, iron and other metals. The gene is associated with iron import into the cell, copper ion import, cellular response to iron ion starvation, iron homeostasis, iron transport, and filamentous growth. The encoded product localises to the ER membrane and the plasma membrane. FREB has been associated with vascular wilt disease and with Nicotiana benthamiana interactions. Studies of related genes in other species link the family to ferric-chelate reductase (NADPH) activity.