ASP1 — Verticillium dahliae

Summary

VDAG_06846 (VdASP1) in Verticillium dahliae encodes an asparaginase (EC 3.5.1.1) with a conserved L-asparaginase domain, and is annotated to asparagine breakdown. The gene is associated with a wide range of phenotypes, including abnormal flocculation, biofilm formation, adhesion, colony morphology, cell wall morphology, and pseudohyphal growth. It is also linked to altered vegetative growth rate, invasive growth, respiratory metabolism, cell cycle progression in G1 phase, stress resistance, and replicative lifespan. The encoded protein is predicted to localize to the cytoplasm, periplasm, and cell-bound compartments. Studies of related genes in other species connect the family to filamentous growth and UV resistance, though these associations are not yet established for VdASP1 itself.