CYC8 — Verticillium dahliae

Summary

VDAG_07052, designated VdCYC8 (also known as VdSSN6 or VdRCM-1) in Verticillium dahliae on chromosome DS572709, encodes a corepressor-demethylase family protein containing tetratricopeptide repeat (TPR) domains. The product possesses chromatin DNA binding and transcription corepressor activity, and binds RNA polymerase II cis-regulatory region sequence-specific DNA. VdCYC8 is associated with negative regulation of transcription by RNA polymerase II, the glucose effect, sporulation, and DNA-dependent transcription. The protein localises to the nucleus, cytoplasm, chromatin, and the transcription repressor complex. This gene has been connected to vascular wilt disease in cotton (Gossypium hirsutum). Studies of related genes in yeast link the family to the Tup11/Tup12 repressor complex and, through sequence similarity, to oxidative stress response.