ACS1 — Verticillium dahliae

Summary

VDAG_07057 (VdACS1, also known as VdFACA or ACU-5) in Verticillium dahliae encodes an acetyl-coenzyme A synthetase with acetate-CoA ligase and amide synthase activities, belonging to the AMP-binding enzyme superfamily. The gene is associated with acetyl-CoA biosynthesis, acetate and acetoin catabolism, ethylene anabolism, penicillin biosynthesis, and heterotrophy. It has been linked to abnormal carbon source utilization, decreased hypoosmotic stress resistance, absent nutrient uptake and adhesion, altered pheromone production and sensitivity, reduced fermentative growth, increased X-ray resistance, and sterility. The encoded protein is localized to the cytoplasm, cytosol, mitochondria, nucleus, and nucleolus, and is also detected extracellularly. Related genes in other species have been linked to protein content and unaffected pathogenicity.