FREB — Verticillium dahliae

Summary

VDAG_07239 (FREB) in Verticillium dahliae encodes a metalloreductase with ferric-chelate reductase (NADPH) activity, possessing ferric/cupric reductase and FAD-binding domains. The gene is associated with iron import into the cell, copper ion membrane transport and import, cellular response to iron ion starvation, and cellular iron ion homeostasis. It is linked to the plasma membrane and ER membrane. Studies of related genes in other species connect the FREB family to reduced virulence and vascular wilt, though these associations are not yet established for V. dahliae itself.