AAC — Verticillium dahliae

Summary

VDAG_07535, designated VdAAC, encodes a mitochondrial carrier protein of the ADT_euk_type family, with annotated molecular functions including ATP/ADP exchange, thiamin permease activity, thiamine diphosphate transporter activity, and ATP binding. Localised to the mitochondrial inner membrane, it is associated with heme transport, regulation of mitochondrial membrane permeability, anaerobic respiration, sporulation, and mitochondrial thiamine pyrophosphate transmembrane transport. Phenotypic associations include abnormal flocculation, increased adhesion and necrotic cell death, decreased lifespan, delayed mitophagy, absent anaerobic growth, and altered nitrogen source utilisation. The gene is also linked to reduced respiratory growth and oxidative phosphorylation, as well as increased mitochondrial genome maintenance. Related genes in other species connect the gene to reduced virulence.