ILV1 — Verticillium dahliae

Summary

VDAG_07872 (VdILV1) encodes a protein with acetolactate synthase large subunit and TPP-binding domains, and is annotated with acetolactate synthase activity, 2-hydroxyacyl-CoA lyase activity, TPP binding, magnesium binding, and FAD or FADH2 binding. VdILV1 is associated with valine, isoleucine and leucine biosynthesis, and with fatty acid alpha-oxidation. The protein localises to the acetolactate synthase complex, mitochondria, peroxisomes and cytosol. VdILV1 is associated with vegetative growth, sporulation efficiency, osmotic stress resistance, cell cycle progression, autophagy, pseudohyphal growth, fermentative metabolism, prion formation and loss, and viability. Studies of related genes in other species connect the family to loss of pathogenicity and cryptococcosis.