AM — Verticillium dahliae

Summary

VDAG_08339 (VdAM) encodes a glutamate dehydrogenase (NADP+) enzyme, belonging to the Glu/Leu/Phe/Val/Trp dehydrogenase family. In Verticillium dahliae, this gene is associated with nitrate assimilation, detoxification, and cellular responses to farnesol and nitrosative stress. It is linked to penetration peg formation and localizes to both the cytosol and extracellular space. Phenotypic associations include decreased necrotic cell death, abnormal filamentous growth, reduced nutrient uptake and utilization of nitrogen, phosphorus, and iron sources, increased osmotic stress resistance, and increased vegetative growth rate. The gene is also associated with abnormal redox state, peroxisomal morphology and transport, vacuolar transport, cell cycle progression, and increased silencing and mating response. Studies of related genes in other species link the family to NADP+-specific glutamate dehydrogenase activity.