SEC22 — Verticillium dahliae

Summary

VDAG_08386, designated VdSEC22 (SEC22) on chromosome DS572714 of Verticillium dahliae, encodes a SNARE protein containing a Longin domain and a V_SNARE_CC motif. The gene is associated with vesicle fusion, particularly ER-to-Golgi and cis-Golgi-to-rough ER transport, as well as protein secretion, intracellular protein transport, and septin ring organization. Its product localizes to the ER membrane, Golgi membrane, COPII-coated vesicle membrane, ER exit site, and SNARE complexes. VdSEC22 is associated with vascular wilt disease of Gossypium hirsutum. Phenotypic associations include abnormal Golgi and ER distribution, absent vacuolar transport and flocculation, decreased cell cycle progression and spore germination, and altered cell death and nutrient uptake. Related genes in other species are linked to vesicle trafficking and membrane fusion processes.