ACS2 — Verticillium dahliae

Summary

VDAG_08654 (ACS2) on chromosome DS572715 of Verticillium dahliae encodes an acetyl-coenzyme A synthetase, a member of the AMP-binding enzyme superfamily. The gene product exhibits propionate-CoA ligase, amide synthase, and acetate-CoA ligase activities, and binds AMP and ATP. ACS2 is associated with ethylene anabolism, acetoin and acetate breakdown, pyruvate fermentation to acetate, acetyl-CoA anabolism, penicillin anabolism, and heterotrophy. The protein has been linked to the nucleolus, extracellular region, endoplasmic reticulum, and cytosol. Sequence similarity studies in related fungi connect the ACS2 family to acetate-CoA ligase activity (EC 6.2.1.1).