ADA1 — Verticillium dahliae

Summary

VDAG_08850 (VdADA1) encodes an AMP deaminase (EC 3.5.4.6) with AMP deaminase activity and metal binding, placing it in the AMPD family of metal hydrolases. The gene is associated with IMP anabolism and salvage, AMP metabolism, melanin anabolism, and chromatin modeling, and its product localizes to the cytosol. VdADA1 is linked to numerous phenotypes including abnormal Golgi morphology, increased freeze-thaw resistance, decreased fermentative metabolism, absent budding and cytokinesis, decreased meiosis, increased pheromone sensitivity, decreased nutrient uptake and phosphorus utilization, decreased cold sensitivity, absent autophagy and cell death, and decreased protein secretion. Related genes in other species are linked to oxidative stress response and biofilm formation. VdADA1 also shows associations with genes such as TLC1, APT1, and AMD1.