RSC8 — Verticillium dahliae

Summary

VdRSC8 (VDAG_09045) on chromosome DS572718 of Verticillium dahliae encodes a transcription regulatory protein SWI3. The product contains SWIRM, SANT/Myb and SMARCC_C domains, binds DNA, histones and zinc, and localises to the nucleus, cytoplasm, chromatin and the SWI-SNF and PBAF complexes. It is associated with regulation of RNA polymerase II transcription, chromatin-mediated transcription maintenance, DNA-dependent transcription, cell projection morphogenesis, nuclear export and host interaction. Phenotypic associations link the gene to increased transposable element transposition, altered cell cycle progression (premature G1/S, delayed G2/M and S phases, delayed metaphase), absent mating-type switching, decreased adhesion and filamentous growth, abnormal bud neck morphology, cytokinesis and cell size, increased flocculation and mutation frequency, and decreased colony size and X-ray resistance.