TOR — Verticillium dahliae

Summary

VDAG_09065, designated VdTOR, encodes a protein on chromosome DS572717 of Verticillium dahliae. The product contains multiple domains including the FRB, FAT, FATC, PI3/4-kinase catalytic, and HEAT repeat regions, and exhibits pre-rRNA binding, and ATP binding. VdTOR is a component of the TORC1 and TORC2 complexes and localises to nucleolar chromatin and the perinuclear cytoplasm. It is associated with TORC2 signalling, DNA damage response, chemotropism, regulation of macroautophagy, and positive regulation of cytoplasmic translation and ribosomal protein gene transcription. Phenotypic associations link VdTOR to increased virulence, abnormal spore germination, absent sporulation efficiency, altered cell cycle progression, and changes in carbon and nitrogen source utilisation. Studies of related genes in other species connect the family to oxidative stress response and turgor pressure.