GTR1 — Verticillium dahliae

Summary

VDAG_09326 (GTR1, VdGTR1) of Verticillium dahliae encodes a RagA/Gtr1 family P-loop NTPase with GTPase activity and GTP binding, and also possesses protein serine/threonine kinase activator activity. The gene is associated with chemotropism, hyphal growth, mating, and both positive and negative regulation of TORC1 signaling. It is linked to cellular responses to starvation, negative regulation of autophagy, and negative regulation of the mitotic-to-meiotic cell cycle switch. The encoded protein localises to the Gtr1-Gtr2 GTPase complex, the fungal-type vacuole membrane, the cytosol, and the nucleus. Phenotypic associations include abnormal carbon source utilisation, abnormal flocculation, absent biofilm formation, delayed pexophagy, increased cell death rate, and abnormal replicative lifespan. Related genes in other species link the family to oxidative stress response.