CMR1 — Verticillium dahliae

Summary

VDAG_09539, designated VdCMR1, encodes a WD40 repeat-containing protein in Verticillium dahliae (chromosome DS572720). The product is annotated with DNA-binding molecular function and is associated with regulation of melanin anabolism, secondary metabolism, hyphal growth, and DNA damage checkpoint and repair processes. The protein localises to the nucleus, chromatin, nuclear periphery, and cytoplasm. Phenotypic associations link VdCMR1 to cell cycle progression (including G1/S and G2/M phase transitions), chromosome segregation, meiotic recombination, spore wall formation, spindle pole body positioning, and resistance to ionising radiation, UV, and X-rays. The gene is also associated with increased mutation frequency, abnormal nuclear export, increased aneuploidy, and decreased apoptosis. Studies of related genes in other species associate the family with decreased heat sensitivity and starvation resistance.