FLO8 — Verticillium dahliae

Summary

VDAG_09783 (VdFLO8) encodes a mediator of RNA polymerase II transcription subunit 15, a transcriptional co-regulator that is part of the Mediator complex. In Verticillium dahliae, this gene is associated with the regulation of transcription by RNA polymerase II. It has been linked to the oxidative stress response and to numerous cell cycle phenotypes, including increased duration of cell cycle progression, delayed G1/S and G2/M phase transitions, abnormal mitotic cell cycle, and altered cell size at the G1 checkpoint. The gene is also associated with increased resistance to gamma rays, X rays, UV, and acid pH, as well as decreased mating response, abnormal pseudohyphal growth, and altered vegetative growth. Studies of related genes in other species link the family to cellulose content and acid sensitivity.