VPS36 — Verticillium dahliae

Summary

VDAG_09891, designated VdVPS36 on chromosome DS572723 of Verticillium dahliae, encodes a Vps36-NZF-N and GLUE domain-containing protein that binds phosphatidylinositol-3-phosphate, ubiquitin, and zinc. It is a component of the ESCRT II complex and localizes to the late endosome membrane, Golgi complex, and cytoplasm. The gene is associated with defense response, late endosome-to-vacuole transport, ubiquitin-dependent protein breakdown via the MVB pathway, and host invasion. Phenotypic associations include abnormal endocytosis, absent vacuolar transport, altered autophagy and nucleophagy, increased necrotic cell death, decreased lifespan, and altered cell cycle progression. The gene is also linked to increased ionic stress resistance, decreased anaerobic growth, and altered pheromone production and sensitivity. Studies of related genes in other species connect the VPS36 family to calcium and acid sensitivity.