AHA1 — Verticillium dahliae

Summary

VDAG_10067 (VdAHA1) on Verticillium dahliae chromosome DS572725 encodes a protein with ATPase activator activity and chaperone protein binding, containing AHSA1_N and ASHA1-like_C domains and a START-like domain superfamily fold. The gene is associated with protein folding, homologous recombination, and ergosterol anabolism, and its product localises to both the cytosol and nucleus. VdAHA1 has been connected to vascular wilt in cotton (Gossypium hirsutum). Associations include abnormal cell cycle progression, increased thermotolerance, decreased radiation resistance, abnormal silencing, mitochondrial genome maintenance defects, altered vegetative growth and sporulation, abnormal budding and chromosome segregation, decreased respiratory metabolism, and abnormal cellular and nuclear morphology. Studies of related genes in other species link the AHA1 family to decreased viability.