AFL1 — Verticillium dahliae

Summary

VDAG_10441 (AFL1, also known as VdAFL1, VdASP1, VdVIP1, VIP1, or ASP1) in Verticillium dahliae encodes a protein with ATP-grasp_RimK-type and VIP1_N domains, and exhibits inositol hexakisphosphate 1-kinase, 5-diphosphoinositol pentakisphosphate 1-kinase, and inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activities, along with ATP binding and 2Fe-2S cluster binding. The gene is associated with inositol phosphate metabolism and breakdown, regulation of bipolar cell growth, mitotic spindle elongation, microtubule dynamics, asexual reproduction, signaling, and intracellular phosphate homeostasis. It is linked to the cytoskeleton, cytosol, and nucleus. Phenotypic associations include altered spore germination, cell cycle progression, budding patterns, pseudohyphal growth, endocytosis, nutrient uptake, alkaline pH resistance, and cytoskeleton morphology.