LAC1 — Verticillium dahliae

Summary

VDAG_00189, symbol LAC1, on Verticillium dahliae chromosome DS572695, encodes a multicopper oxidase of the CuRO_2_Fet3-like family with ferroxidase activity, copper binding and iron channel activity. The gene is associated with reductive iron assimilation, cellular response to iron ion starvation, arsenate ion transmembrane transport, response to copper, cellular copper ion homeostasis, pigment and melanin anabolism, and localises to the high-affinity iron permease complex, fungal biofilm matrix, cell-bound and extracellular compartments. Studies of related genes in other species link the family to fusarium ear blight, though those studies also report unaffected pathogenicity in some contexts.