FRH — Verticillium dahliae

Summary

VDAG_00172 (FRH) in Verticillium dahliae encodes a DEAD/DEAH-box helicase with RNA helicase activity, ATP binding, and nucleic acid binding, placing it in the SKI2 subfamily of helicases. The FRH protein is associated with multiple RNA processing and surveillance pathways, including polyadenylation-dependent noncoding RNA catabolism, sno(s)RNA processing, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, and the TRAMP-dependent tRNA surveillance pathway. It has been linked to heterochromatin island assembly, degradation of meiosis-specific transcripts, non-stop decay, and the endoplasmic reticulum unfolded protein response (erUPR). The protein localizes to the Ski complex, TRAMP complex, NURS complex, nucleolus, nucleus, and cytoplasm. Related genes in other species connect the FRH family to helicase activity and RNA metabolism.