TSC2 — Verticillium dahliae

Summary

VDAG_09981 (VdTSC2, symbol TSC2) encodes tuberin, a protein with Rap/Ran-GAP domain and GTPase-activating protein (GAP) activity. In Verticillium dahliae, VdTSC2 is associated with negative regulation of TOR signaling, positive regulation of autophagy, regulation of small GTPase-mediated signal transduction, chemotropism, hyphal growth, mating, and negative regulation of G1/S transition of the mitotic cell cycle. It is also linked to upregulation of L-leucine import and activation of L-arginine uptake. The protein localizes to the TSC1-TSC2 complex, cell division site, cytoplasm, cytosol, and nucleus.