PTC1 — Verticillium dahliae

Summary

VdPTC1 (VDAG_09695) on chromosome DS572722 of Verticillium dahliae encodes a protein phosphatase 2C ABI1 with MAP kinase serine/threonine phosphatase activity, protein serine/threonine phosphatase activity, adenylyl cyclase activity, ATP binding, and metal binding. It belongs to the PP2C and PPM-type phosphatase families. The gene is associated with conidium development, downregulation of MAPK cascade, downregulation of p38 cascade, cAMP anabolism, endoplasmic reticulum unfolded protein response, cellular osmotic response, intracellular signal transduction, fungal-type cell wall organization, and signal transduction. Its product localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity, though this is not established for V. dahliae.