PTC5 — Verticillium dahliae

Summary

VdPTC5 (VDAG_08880) on chromosome DS572718 of Verticillium dahliae encodes a protein serine/threonine phosphatase with pyruvate dehydrogenase (lipoamide) phosphatase activity, belonging to the PP2C/PPM-type phosphatase family. The gene is associated with conidium development, the pyruvate dehydrogenase pathway, and metal binding. Its product localises to mitochondria, the mitochondrial envelope lumen, peroxisomes, cytoplasm, and nucleus. Phenotypic associations link VdPTC5 to decreased vegetative growth, sporulation, and invasive growth, as well as increased autophagy and mitophagy, abnormal mitochondrial distribution, and altered stress resistance. The gene is also connected to cell cycle arrest in G1 phase, decreased telomere length, and abnormal budding and colony morphology. Studies of related genes in other species link the family to oxidative stress response and sporulation efficiency.