SNF1 — Verticillium dahliae

Summary

VDAG_08621, designated VdSNF1 (also known as SSP2, VdSSP2, PRK-10, VdPRK-10) in Verticillium dahliae on chromosome DS572715, encodes a serine/threonine protein kinase with protein kinase A activity, ATP binding, and phospholipid binding. The product belongs to the SNF1_UBA, AMPK_C, and KA1/Ssp2_C domain families. VdSNF1 is associated with the CAMKK-AMPK signaling cascade, cellular response to glucose starvation, regulation of invasive growth in response to glucose limitation, upregulation of gluconeogenesis and macroautophagy, and negative regulation of translation and filamentous growth. It is also linked to fungal-type cell wall assembly, septin ring assembly, single-species surface biofilm formation, and mycose catabolism. The protein localizes to the nucleotide-activated protein kinase complex, nuclear membrane, vacuolar membrane, and cellular bud neck. Studies of related genes in other species link the family to loss of pathogenicity and turgor pressure.