CDC34 — Verticillium dahliae

Summary

VDAG_08487 (VdCDC34) encodes a ubiquitin-conjugating enzyme with ubiquitin conjugating enzyme activity, ssDNA-dependent ATPase activity, ssDNA binding, ATP binding, and proteasome binding. It is associated with protein polyubiquitination, the stress-induced homeostatically regulated protein degradation pathway, the INMAD pathway, negative regulation of the SREBP signaling pathway, phenylpropanoid metabolism, regulation of dipeptide transport, ubiquitin-dependent protein breakdown via the N-end rule pathway, mitotic G1 DNA damage checkpoint, meiotic DNA double-strand break formation, error-free translesion synthesis, telomere maintenance via recombination, and sno(s)RNA transcription. The gene is linked to phenotypes including abnormal lifespan, increased sporulation, delayed cell cycle progression in mid anaphase, premature G2/M phase transition, increased rate of G1/S phase transition, increased shmoo formation, and delayed pexophagy. It localizes to the UBR1-RAD6 complex, Rad6-Rad18 complex, HULC complex, ubiquitin ligase complex, endoplasmic reticulum, cytoplasm, cytosol, and nucleus.