CHS1 — Verticillium dahliae

Summary

VDAG_08591 (CHS1, VdCHS1) encodes a chitin synthase with chitin synthase activity (EC 2.4.1.16), containing chitin synthase N-terminal and nucleotide-diphosphosugar transferase domains. The gene is associated with chitin anabolism, cell wall organization, hyphal growth, and conidia formation in Verticillium dahliae. The encoded protein localizes to the plasma membrane, hyphal tip, porous cell septum, and cross wall. VdCHS1 is linked to vascular wilt disease in cotton (Gossypium hirsutum) and Arabidopsis thaliana. Phenotypic associations include abnormal chitin deposition, septum formation, spore wall formation, bipolar budding, cell cycle progression, vesicle distribution, mating projection morphology, and decreased flocculation, adhesion, and cell death. Related genes in other species are linked to polysaccharide content, septum formation, vegetative growth, and pathogenicity.