PP2A — Verticillium dahliae

Summary

VDAG_07906, designated VdPP2A (also known as VdPPG1, VdPPA3), encodes a protein serine/threonine phosphatase of the PP2A family, possessing protein phosphatase activity and metal binding. In Verticillium dahliae, this gene is associated with the negative regulation of mitophagy, the DNA damage checkpoint, and the mevalonate pathway, as well as positive regulation of non-homologous end joining. It is linked to the regulation of TORC1 signaling, cell shape, cytoplasmic translation, and septation initiation. The encoded product localizes to the PP2A complex, nuclear periphery, mitochondrial outer membrane, and chromatin. Phenotypic associations include abnormal cell cycle progression, decreased pheromone sensitivity, increased mitophagy, and altered stress resistance. Studies of related genes in other species link the family to reduced virulence.