CDC11 — Verticillium dahliae

Summary

VDAG_07687, designated VdCDC11, encodes a leucine-rich repeat-containing protein with adenylyl cyclase activity, protein phosphatase activator and regulator activities, and signaling adaptor activity. It binds ATP and magnesium. The gene is associated with cell division processes including mitosis, cytokinesis, regulation of mitotic cytokinesis, activation of mitotic sister chromatid resolution and division septum assembly, and upregulation of the metaphase/anaphase transition. It is linked to cAMP anabolism, intracellular signal transduction, nuclear movement, and the septation initiation network (SIN). The product localizes to the mitotic and meiotic spindle pole body, the SIN/MEN signaling complex, the PTW/PP1 phosphatase complex, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity and protein content.