FRH — Verticillium dahliae

Summary

VDAG_07754 (VdFRH) encodes an FRQ-interacting RNA helicase belonging to the SKI2-like family, with RNA helicase, ATP hydrolase, and nucleic acid binding activities. In Verticillium dahliae, VdFRH is associated with diverse RNA processing events including spliceosome conformational changes, polyadenylation-dependent ncRNA catabolism, sno(s)RNA processing, siRNA catabolism, nuclear mRNA surveillance, 5.8S rRNA maturation, and non-stop decay. It is also linked to rhythmic processes, heterochromatin island assembly, flocculation, and the endoplasmic reticulum unfolded protein response. The protein localizes to the spliceosome, nucleolus, cytoplasm, and nuclear bodies. Phenotypic associations include altered cell cycle progression, chromosome segregation defects, abnormal septum formation, increased budding, and changes in mitochondrial mutation frequency and phosphorus utilization. Studies of related genes in other species link the family to the TRAMP and NURS complexes.