ERG4 — Verticillium dahliae

Summary

VDAG_07075 (VdERG4) on chromosome DS572709 of Verticillium dahliae encodes a sterol Delta(7)-reductase belonging to the ERG24_DHCR-like family, with 7-dehydrocholesterol reductase, D24(24-1)-sterol reductase and D14-sterol reductase activities, and NADP binding. The gene is associated with ergosterol, cholesterol and brassinosteroid anabolism, filamentous growth in response to biotic stimulus, and cellular response to xenobiotic stimulus. Its product localises to the endoplasmic reticulum membrane. VdERG4 is associated with abnormal bipolar budding, decreased endocytosis, abnormal plasma membrane and cell wall morphology, sterility, decreased cell fusion, altered pheromone response, decreased shmoo formation, increased cell death, decreased invasive growth, decreased nutrient uptake, decreased cold sensitivity, and altered iron and phosphorus utilisation.