PTC4 — Verticillium dahliae

Summary

VDAG_07016 (VdPTC4) on chromosome DS572709 of Verticillium dahliae encodes a protein serine/threonine phosphatase with MAPK phosphatase activity, belonging to the PP2C and PPM-type phosphatase families. The gene is associated with conidium development, positive regulation of vacuole fusion, regulation of aerobic respiration, downregulation of MAPK and p38 cascades, cellular osmotic response, signal transduction, and cellular response to oxidative stress. Its product localizes to the fungal-type vacuole membrane, mitochondria, mitochondrial lumen, cytoplasm, cytosol, and nucleus. VdPTC4 is linked to numerous phenotypes including absent filamentous growth, decreased colony size, increased alkaline pH resistance, decreased cold sensitivity, altered respiratory and fermentative metabolism, abnormal mitophagy and nucleophagy, and increased entry into G0 stationary phase. Studies of related genes in other species connect the family to turgor pressure, phosphate content, and acid sensitivity.