STV1 — Verticillium dahliae

Summary

VdSTV1 (VDAG_06927) in Verticillium dahliae encodes a 116-kDa subunit of the vacuolar-type ATPase V0 domain, with ATPase and proton-transporting ATPase activities. The gene is associated with vacuolar acidification, proton transmembrane transport, invasive growth, and sporulation. It localises to the vacuolar proton-transporting V-type ATPase complex, the fungal-type vacuole membrane, and the endoplasmic reticulum. Phenotypic associations include absent alkaline pH resistance, abnormal vacuolar distribution, decreased cell death, increased entry into G0 stationary phase, and altered cell cycle progression through G2/M. The gene is also linked to decreased chemical compound accumulation, absent small molecule transport, and abnormal Golgi morphology. Related genes in other species connect the family to vacuolar acidification and ion homeostasis, while sequence similarity links VdSTV1 to traits such as zinc and calcium sensitivity in other fungi.